Methods for preparing functional tetraazacycloalkane compounds using a specific cyclic bisaminal compound (WO2013072491)
This patent allows to elaborate a large variety of C-functionalized tetraazamacrocyles from the protected oxocyclam (A). TETA (E), TE2A (F) and CB-TE2A (G) derivatives are obtained from the protected cyclam intermediate (B). The protected oxocyclam (A) is conveniently used to generate mono N-functionalized cyclams (C) and cross-bridged cyclams (D), which offer the possibility to access dissymmetric TETA (H) or CB-TE2A (I).
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